The problem is that we're often led to believe that we need to think outside the box, but actually the most creative solutions often come from people who have gone so deep into a box that they understand the nuances and the constraints so well that they can find new pathways within it that others couldn't see.

David Epstein — EconTalk

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Will Durant spent his whole life worrying that he was a failure. He wrote 13 volumes of The Story of Civilization over 50 years, a project so vast it seems almost incomprehensible. And he was worried he was a failure.

Hidden Brain

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For most of human history, people were infected with intestinal worms. The worms, in turn, evolved to modulate their hosts' immune responses — keeping inflammation in check so the host could survive and the worms could keep living inside them. The modern, wormy-free immune system, the hypothesis goes, never got that memo and remains primed to overreact.

Radiolab

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