A core part of JFK's message was that innovation without inclusion is not progress; it is a slow-motion eviction of the American worker from their own economy.
As AI tools become more widely used and increasingly specialized, many business leaders are trying to think quickly and creatively about how to best utilize this technology at nearly every level of their operations.
The belief for years has been that pancreatic tumors were an immune desert because it has too few mutations to flag and too dense a stromal wall to penetrate. This trial suggests the wall can be climbed, if you give the immune system the right map: a personalized neoantigen set, manufactured in weeks, and delivered as mRNA.
Why you need to build products that don't yet fully work, so you're ready when the next model closes the gap
2w ago
The best ideas have some magical quality where one day they seem impossible, and the next day they seem inevitable. The hard part is being in the room when the transition happens.
We believe in saying no to thousands of projects so that we can really focus on the few that are truly important and meaningful to us. We believe in deep collaboration and cross-pollination of our groups, which allow us to innovate in a way that others cannot.
So much money and attention is focused on re-thinking our work tools and processes today, Gavini notes, with many of tech's smartest people bringing AI to verticals like legal or healthcare. "My workflow changes every three months now," he says. "So why are the apps that I use on my phone every day still the same?"
Those early adopters found, to their surprise, not only that the models were good at puzzles, but that they could help break genuinely new ground. Soon, mathematicians were using AI to discover and prove new results, accomplishing in a day what would have once taken them weeks or months.
A trap a lot of these kinds of research labs or hard tech labs fall into is they start with the technology first, build that in a vacuum, and then they try to figure out what use cases to try to fit it into later. Whenever that happens, it always feels like the product isn't quite the right fit.
What Arc and the OpenAI Foundation are doing is what private capital and motivated foundations can do that institutional science usually can't: pick a hard problem, fund a full-stack experimental-and-AI engine, and run the loop fast enough that we might actually get somewhere by the time it matters to my family.
4w ago
The only way to discover the limits of the possible is to go beyond them into the impossible.
The exterior of the Las Vegas Sphere, known as the Exosphere, is a 580,000-square-foot LED display wrapping a 366-foot-tall, 516-foot-wide spherical structure. This colossal screen is composed of 1.2 million individual "LED pucks," each containing 48 LEDs, to create a dynamic and high-resolution visual experience.
A start-up company wants to light up the night with 50,000 big mirrors orbiting Earth, bouncing sunlight to the night side of the planet to power solar farms after sunset, provide lighting for rescue workers and illuminate city streets, among other things.
2mo ago
The best ideas have a lifespan. At first, they're attacked viciously. Then they're accepted as obvious. The violence of the attacks is proportional to how good the idea is.
The problem with fringe ideas is that most of them are wrong, but the few that are right are very, very valuable. For me, it was always thinking about, 'am I crazy, or is there something here?'
2mo ago
The discoverer of a new scientific truth does not gradually win over his opponents by converting them... What does happen is that his opponents gradually die, and a new generation grows up that is familiar with the idea from the beginning.
2mo ago
The one thing we ask is that the man who is not thinking should get out of the way of the man who is. The world wants to move forward, and if you're not moving with it, you're holding it back.
The exterior of the Las Vegas Sphere, known as the Exosphere, is a 580,000-square-foot LED display wrapping a 366-foot-tall, 516-foot-wide spherical structure. This colossal screen is composed of 1.2 million individual "LED pucks," each containing 48 LEDs, to create a dynamic and high-resolution visual experience (translation: blows your got dang socks off).
One rebuttal — which I happily ascribe to — is to reply with an image of Las Vegas Sphere and say, "yes, we definitely do." Look, the latter might not be the Cathedral Notre Dame or La Sagrada Familia…or the Forbidden Palace. But it's still a different kind of marvel and incredible engineering accomplishment.
Devevillance's Spectre I, developed by a recent Harvard grad, wants to give people control over the always-on wearables surrounding their lives. The problem? Physics.
It used to be a one-year strategic plan. You would lay out, 'Okay, we're going to do this, we're going to do that.' Now you're like, 'All right, let's go see if you can make this work, two days later. And it works.'
2mo ago
We are all agreed that your theory is crazy. The question that divides us is whether it is crazy enough to have a chance of being correct.
2mo ago
It is the tension between creativity and skepticism that has produced the stunning and unexpected findings of science.
2mo ago
Underscored — save the words that stop you in your tracks.
