notboring.co

Weekly Dose of Optimism #190

The belief for years has been that pancreatic tumors were an immune desert because it has too few mutations to flag and too dense a stromal wall to penetrate. This trial suggests the wall can be climbed, if you give the immune system the right map: a personalized neoantigen set, manufactured in weeks, and delivered as mRNA.

lennysnewsletter.com

How Anthropic’s product team moves faster than anyone else | Cat Wu (Head of Product, Claude Code)

Why you need to build products that don't yet fully work, so you're ready when the next model closes the gap

stratechery.com

Tim Cook’s Impeccable Timing

We believe in saying no to thousands of projects so that we can really focus on the few that are truly important and meaningful to us. We believe in deep collaboration and cross-pollination of our groups, which allow us to innovate in a way that others cannot.

upstartsmedia.com

Would You Try This AI-Powered Email App?

So much money and attention is focused on re-thinking our work tools and processes today, Gavini notes, with many of tech's smartest people bringing AI to verticals like legal or healthcare. "My workflow changes every three months now," he says. "So why are the apps that I use on my phone every day still the same?"

3quarksdaily.com

The AI Revolution in Math Has Arrived

Those early adopters found, to their surprise, not only that the models were good at puzzles, but that they could help break genuinely new ground. Soon, mathematicians were using AI to discover and prove new results, accomplishing in a day what would have once taken them weeks or months.

upstartsmedia.com

Robots! Drones! How DoorDash Is Building In Autonomous Delivery

A trap a lot of these kinds of research labs or hard tech labs fall into is they start with the technology first, build that in a vacuum, and then they try to figure out what use cases to try to fit it into later. Whenever that happens, it always feels like the product isn't quite the right fit.

notboring.co

Weekly Dose of Optimism #188

What Arc and the OpenAI Foundation are doing is what private capital and motivated foundations can do that institutional science usually can't: pick a hard problem, fund a full-stack experimental-and-AI engine, and run the loop fast enough that we might actually get somewhere by the time it matters to my family.

readtrung.com

The Sphere's $4B Business, explained

The exterior of the Las Vegas Sphere, known as the Exosphere, is a 580,000-square-foot LED display wrapping a 366-foot-tall, 516-foot-wide spherical structure. This colossal screen is composed of 1.2 million individual "LED pucks," each containing 48 LEDs, to create a dynamic and high-resolution visual experience.

upstartsmedia.com

Star Catcher’s Andrew Rush: Harnessing The Sun To Build The First Energy Grid In Space

Our daily lives are based on and enriched by space, regardless of who we are. So providing more power ultimately enriches humanity.

3quarksdaily.com

A Big Night Light in the Sky? Start-Up Wants to Launch a Space Mirror

A start-up company wants to light up the night with 50,000 big mirrors orbiting Earth, bouncing sunlight to the night side of the planet to power solar farms after sunset, provide lighting for rescue workers and illuminate city streets, among other things.

upstartsmedia.com

Synthesia's Victor Riparbelli On AI Video, Fringe Ideas, And Startup Lies

The problem with fringe ideas is that most of them are wrong, but the few that are right are very, very valuable. For me, it was always thinking about, 'am I crazy, or is there something here?'

readtrung.com

The Sphere's $4B Business, explained

The exterior of the Las Vegas Sphere, known as the Exosphere, is a 580,000-square-foot LED display wrapping a 366-foot-tall, 516-foot-wide spherical structure. This colossal screen is composed of 1.2 million individual "LED pucks," each containing 48 LEDs, to create a dynamic and high-resolution visual experience (translation: blows your got dang socks off).

readtrung.com

The Sphere's $4B Business, explained

One rebuttal — which I happily ascribe to — is to reply with an image of Las Vegas Sphere and say, "yes, we definitely do." Look, the latter might not be the Cathedral Notre Dame or La Sagrada Familia…or the Forbidden Palace. But it's still a different kind of marvel and incredible engineering accomplishment.

wired.com

This Jammer Wants to Block Always-Listening AI Wearables. It Probably Won’t Work

Devevillance's Spectre I, developed by a recent Harvard grad, wants to give people control over the always-on wearables surrounding their lives. The problem? Physics.

upstartsmedia.com

Flexport's Ryan Petersen On Tariff Refunds, AI Agents And How To Win Back Customers

It used to be a one-year strategic plan. You would lay out, 'Okay, we're going to do this, we're going to do that.' Now you're like, 'All right, let's go see if you can make this work, two days later. And it works.'